Butein cell cycle

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August undefined, 2024

WebJun 4, 2024 · It was found that butein notably inhibited cell viability, colony formation, migration and invasion, induced cell cycle at the G2/M stage and cell apoptosis, as well as enhanced caspase-3, -8 and -9 activity in HeLa cells in a dose-dependent manner. WebMar 23, 2024 · Butein suppressed downstream signal transduction through higher binding affinity to IL-6. In ovarian cancer, butein inhibited cell proliferation, migration, and …

p53 causes butein‑mediated apoptosis of chronic myeloid leukemia …

WebInt. J. Mol. Sci. 2010, 11 3 pandurata, induces apoptosis and G2/M cell cycle arrest in androgen-independent prostate cancer cells PC3 and DU145 [14]. Licochalcone A and isoliquiritigenin detected in Glycyrrhiza glabra inhibit proliferation and block cell cycle progression in the G2/M phase in PC3 and DU145 cells [15,16]. Xanthohumol identified … WebIn ovarian cancer, butein inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest and apoptosis, and decreased the growth of ovarian cancer cells in xenograft tumor models. Butea monosperma (Fabaceae) has been used in traditional Indian medicine to treat a variety of ailments, including abdominal tumors. We aimed to … ddjj 7030

Chalcones: Synthetic Chemistry Follows Where Nature Leads

WebButein displays an anti-cancer effect by stimulating an anti-proliferative effect via, for example, inducing cell cycle arrest at the G2/M phase or by stimulating a pro-apoptotic effect via activation of mitochondria-dependent caspase-3 [41,42]. WebFurther experiments revealed butein exposure resulted in a cell cycle arrest at S and G2/M phase in U-2 OS cells. Importantly, this study found that butein activated the tumor … WebThe present invention relates to a carbon nanotube dispersion including carbon nanotubes, a polymer dispersant containing an amine, a phenolic compound including two or more aromatic rings, and an aqueous solvent, wherein the polymer dispersant and the phenolic compound including two or more aromatic rings are included in a weight ratio of 100:1 to … ddjj 7433

Butein Inhibits Cell Growth by Blocking the IL-6/IL-6Rα ... - PubMed

Butein inhibits cell proliferation and induces cell cycle arrest in ...

WebSep 17, 2024 · Butein treatment abrogated the radiation-induced G2/M cell cycle arrest, increased DNA damage, enhanced apoptosis, and reduced colony-forming ability of … WebAug 27, 2014 · The flavonoid butein has been reported to show anti-inflammatory and anti-cancer effects. Following butein treatment of A549 lung cancer cells, quantitative PCR and western blot data demonstrated that COX-2 expression was suppressed at the mRNA and protein levels, respectively, and cell-cycle arrest and apoptosis were induced. ddjj 7622Webassays revealed butein directly interacted with Aurora B and inhibited its kinase activity. Along with the decrease of Aurora B and histone H3 phosphorylation, HCC cells were induced G2/M cell cycle arrest and subjected to cell apoptosis. Butein-mediated antitumor activities were substantially bc stadium parking

"WebMar 1, 2015 · Induces cell-cycle arrest and apoptosis in A549 cells, by downregulating COX-2 mRNA and protein levels: ... could possibly be treated with butein to prevent cell … " - Butein cell cycle

Butein cell cycle

Butein: From ancient traditional remedy to modern …

Web4、tin.2 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.23) Butein suppresses cell proliferation and enhances apoptosis in … WebApr 5, 2016 · In this study, we investigated the anti-leukemic activity of butein and its action mechanisms in ALL. Butein was found to significantly suppress the cellular proliferation …

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Web(B) The clonogenicity of A549 and PC-9 cells after butein treatment. the results are expressed as mean ± SEM, n=6. a P < 0.05 versus control group, b P < 0.05 versus 5 μM butein group, c P < 0. ... www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to …

WebButene, also known as butylene, is an alkene with the formula C 4 H 8.The word butene may refer to any of the individual compounds. They are colourless gases that are present in … WebButein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC). - Mechanism of …

WebButein is a chalcone of the chalconoids. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua ), Dahlia , Butea ( Butea monosperma ) and Coreopsis [1] It … Webbutene, also called Butylene, any of four isomeric compounds belonging to the series of olefinic hydrocarbons. The chemical formula is C4H8. The isomeric forms are 1-butene, …

WebDec 10, 2015 · Additionally, butein mediated cell cycle arrest in S-phase. Therefore, the butein-activated p53 pathway may arrest cells at S-phase, resulting in apoptotic cell death. The present study further demonstrated that butein reduced the protein expression of MDM2 in both p53-expressing KBM5 and p53-null K562 cells, while butein increased the …

WebFeb 7, 2024 · The role of butein in cell cycle distribution was analyzed using the propidium iodide (PI)/RNase staining buffer. Briefly, the cells were incubated in 6-well plates and treated with butein or DMSO for 24 h. Then, the cells were harvested, washed twice with ice-cold PBS, and fixed overnight with precooled 75% ethanol at 4°C. ddjj 931Webof HTLV-1-infected T-cell lines. T cells cultured with butein showed obvious apoptosis morphology, and cleavage of poly(ADP-ribose) polymerase with activation of caspase-3, -8 and -9. Pretreatment of cells with caspase inhibitor partially blocked butein-induced inhibition of cell viability. Butein also resulted in cell cycle arrest at G 1 phase. ddjj etica publica mendozaWebIntroduction. Genomic instability, a tendency of gene alteration during the life cycle of cells, is considered to be the major driving force of tumorigenesis. 1 The genes engaged in the regulation of cell cycle arrest and DNA damage repair are considered to have an important role to maintain the stability of whole genome. 2 p53, a transcription factor which is often … ddjj 7600WebFeb 15, 2024 · Further, butein was also shown to induce cell cycle arrest and apoptosis through the deregulation of COX-2, ICAM-1, and ROS generation, and NF-κB and Akt phosphorylation in lung cancer (Jang et al., 2012, Kim et … bc strain marijuanaWebButein is a chalcone derivative that can be isolated from various plants, including Rhus verniciflua Stokes, Semecarpus anacardium, and Dalbergia odorifera. ... obtusa, Thuja plicata, and Thujopsis dolabrata var. hondai. Yang et al. showed that hinokitiol exposure resulted in cell cycle arrest at the S phase and DNA damage response in both the ... bc stat dayWebSurvivin plays a crucial role in G2/M cell cycle transition and apoptosis inhibition8 ... ˜e cells were treated with Butein, and the whole-cell extract (WCE) was prepared using the commercial ... ddjj domicilioWebButein. Butein (20, 40, 3, 4-tetrahydroxychalcone), is a chalcone that has exhibited a wide range of pharmacological effects such as antiinflammatory, anticancer, antioxidant, and … ddjj etica publica