Clofarabine late effects
http://www.survivorshipguidelines.org/ WebPossible Side Effects Diarrhea Abdominal pain Hand-foot syndrome (tingling of the hands and feet, redness and flaking of the skin) Rash Flushing of the skin Itching Fast …
Clofarabine late effects
Did you know?
WebAug 2, 2024 · Common side effects of clofarabine may include: fever, chills, or other signs of infection; stomach pain, nausea, vomiting, loss of appetite, diarrhea; fast heartbeats; … WebAug 24, 2024 · About: Clofarabine (Clolar ®) Clofarabine is a purine nucleoside analog, which inhibits the enzymatic activities of DNA and RNA. Clofarabine inhibits DNA synthesis, which inhibits the growth of new leukemia cells, interferes with the duplication of DNA, which stops leukemia cells from dividing, and disrupts the mitochondrial membrane, which ...
WebClofarabine shows fewer side effects in comparison to cladribine and fludarabine and also possess favorable pharmacokinetic qualities of both. . ... Clofarabine (12) was given accelerated approval in late December 2004 for use in pediatric acute lymphoblastic leukemia (ALL), based on induction of complete responses in 6 of 49 patients, and 9 ... WebClofarabine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea vomiting stomach pain diarrhea constipation loss of appetite …
WebOct 1, 2006 · Clofarabine is a slightly lipophilic prodrug (mLog P = 0.5) that gains entry into cells by facilitative and active nucleoside transporter mechanisms ( Box 3 ), and, at higher concentrations and... WebThese side effects are less common side effects (occurring in about 10-29%) of patients receiving clofarabine: Low blood pressure; Nosebleeds; Petechiae (small pin-point …
• Tumor lysis syndrome (TLS). Clofarabine quickly kills leukaemia cells in the blood. The body may react to this. Signs include hyperkalemia, hyperuricemia, and hyperphosphatemia. TLS is very serious and can lead to death if it is not treated right away. • Systemic inflammatory response syndrome (SIRS): symptoms include fast breathing, fast heartbeat, low blood pressure, and fluid in the lungs. mステ 三浦春馬 何時Webalkalinize urine throughout the 5 days of Clolar administration to reduce the effects of tumor lysis and other adverse events. Discontinue Clolar if hypotension develops during the 5 days of administration. Monitor renal and hepatic function during the 5 days of Clolar administration [see . Warnings and Precautions (5.6, 5.7)]. mステ 伝説WebFeb 24, 2024 · Pain in arms or legs. Mouth irritation or mouth sores. Signs of a common cold. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-332-1088. mステ 伝説の回Webfainting fast, pounding, or irregular heartbeat or pulse feeling of warmth fever flushing, redness of the skin headache irregular breathing itching in the genital area itching or skin … mステ 何チャンネル 愛知WebAug 2, 2024 · Common side effects of clofarabine may include: fever, chills, or other signs of infection; stomach pain, nausea, vomiting, loss of appetite, diarrhea; fast heartbeats; nosebleeds, bruising; pain in your arms or legs; headache, feeling tired; itching or skin rash; or low blood pressure. mステ 出場者WebDec 19, 2024 · Abstract. Cancer therapy–related cardiac dysfunction (CTRCD) is one of the most concerning cardiovascular side effects of cancer treatment. Important reviews within the field of cardio-oncology have described various agents to be associated with a high risk of CTRCD, including mitomycin C, ifosfamide, vincristine, cyclophosphamide, and … mステ 出演者 次回WebOct 1, 2003 · Limited dog toxicology studies demonstrated lack of toxicities at clofarabine doses of 7.5 mg/kg intravenously over 1 hour daily times 5 days equal to 150 mg/m 2 intravenously over 1 hour daily times 5 days (unpublished data). This resulted in the initiation of a phase 1 study of clofarabine in solid and hematologic cancers in 1998. mステ 何年