Irf7 function

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August undefined, 2024

WebIRF7 plays a major role in the amplification of IFNα production downstream of PRR activation; in most cell types IRF7 is induced by innate IFN priming, however, it is also constitutively expressed in plasmacytoid DCs, where it drives the rapid synthesis of large quantities of IFNα subtypes in response to toll-like receptor (TLR) activation. WebJul 7, 2024 · Thus, interferon-independent functions of STING mediate STING-dependent antiviral responses in vivo. Introduction The immune response to pathogens is initiated upon detection of...

IRFs: master regulators of signalling by Toll-like receptors and

WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established. WebMar 21, 2024 · Molecular function for IRF7 Gene according to UniProtKB/Swiss-Prot In the absence of viral infection, maintained as a monomer in an autoinhibited state and … small car hire perth

3665 - Gene ResultIRF7 interferon regulatory factor 7 [ (human)]

WebOct 10, 2014 · IRF7 is essential for inducing the expression of the type I IFN gene, 6, 12 the negative regulator of arterial intimal lesions in vivo and in vitro, 13, 14 which suggests that IRF7 potentially affects neointima formation. WebNov 3, 2024 · IRF7 is considered more important in amplification of an antiviral response, post-induction ( Sharma et al., 2003 ). IRFs Are Highly Expressed across Bat Tissues In Vivo To validate expression, IRF1 mRNA levels were examined using a cDNA panel generated from 10 tissues isolated from 3 bats/mice ( Figure 2 A). WebDec 23, 2011 · In concordance with this, we show that levels of IRF7 are increased with EAE severity. Thus, the increased IRF7 expression may represent a protective function for IRF7 in EAE. The mechanism by which type I IFNs regulate CNS inflammation has been shown to include reduction of leukocyte migration to the CNS and inhibition of T cell responses [23 ... small car in minecraft

IRF7 - Immune infiltration in stomach adenocarcinoma IJGM

Anti-IRF7 Antibodies Invitrogen - Thermo Fisher Scientific

WebAug 29, 2013 · The interferon-alpha response is an essential component of the host immune response to viral infections, but may contribute to AIDS progression if it persists indefinitely, as occurs in HIV-infected humans and AIDS-susceptible macaque monkeys. WebThe observed association might be attributable to its close proximity with interferon regulatory factor 7 ( IRF7 ), because the strong LD ( r2 = 0.94) between this disease-associated SNP and a 3′ UTR PHRF1 SNP (rs702966) is within 0.6-kb flanking region of the IRF7 gene (51). IRF7, similar to IRF5, is a transcription factor that can activate ... small car insurance companies charlotteWebApr 14, 2011 · IRF7: activation, regulation, modification and function Introduction. Interferon regulatory factors (IRFs) are a family of transcription factors comprised of nine members... Activation of IRF7. Activation of IRF7 is prerequisite for its functions as a transcription … somerset county council david fothergill

"WebIn the present study, we used both gain-of-function and loss-of-function approaches to decipher the potential role of IRF7 in pathological cardiac hypertrophy. For the first time, we observed that overexpression of IRF7 in the heart limited chronic pressure overload–induced cardiac remodeling, whereas loss of IRF7 resulted in detrimental ... " - Irf7 function

Irf7 function

Entry - *605047 - INTERFERON REGULATORY FACTOR 7; IRF7

WebSystemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7). WebApr 4, 2024 · IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-beta-mediated NK activity. The MYC is shown to be recruited to the IRF7 promoter region …

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WebIn order to clarify the role of IRF7 in STAD, we further performed an enrichment analysis of IRF7 in STAD using the Function module of LinkedOmics. IRF7-associated gene analysis … WebIRF7. IRF7 was originally cloned as a factor that bound to a promoter region in the Epstein-Barr virus using a yeast one-hybrid system (Zhang and Pagano, 1997). IRF7, once induced, …

WebMar 26, 2015 · IRF7 can be activated by RIG-I recognition of IAV genomic RNA, resulting in C-terminal serine phosphorylation by the IKK-related kinases TBK1 and IKK-ε ( 11, 14 – 20 ). Wild-type IRF7 was phosphorylated upon overexpression of TBK1, as was F410V ( Fig. 1D ).

WebIRF7 is required for the production and amplification of the antiviral type I (IFN-α/β) and III (IFN-λ) IFNs. The patient's fibroblasts displayed impaired IFN-β and IFN-λ1 production in … WebJan 11, 2024 · Induction of IRF7 and other ISGs is mediated by IFN-I-dependent or IFN-III-dependent receptor dimerization that culminates in the activation and assembly of a transcriptional complex termed...

WebJun 2, 2024 · Ciancanelli and colleagues reported on a 7-year-old girl with life-threatening ARDS from pandemic H1N1 2009 influenza A virus who was found to have compound heterozygous IRF7 variants leading to a loss of IRF7 function and impaired production of type I and III IFNs in response to influenza infection.

WebApr 13, 2024 · Knockdown of IRF7 showed the function of IRF7, the enriched in GO:BP terms of “Defense response to virus”, “Translation”, and “Immune system process” were found in the genes from the CRISPRi cell lines. Significant enrichment was found in the KEGG pathways known as “Influenza A”, ... small caribbean islands vacationsWebApr 2, 2024 · Interferon regulatory factor 7 (IRF7) is known as the master transcription factor of the type I interferon response in mammalian species along with IRF3. Yet birds only … somerset county council crewkerne ilminsterWebSep 6, 2024 · Previously, we found that IRF3 and IRF7 could mediate the acquisition of new anti-tumor effector functions in macrophages . In the present study, we observed that high IRF3 and IRF7 expression was related to CD4 + T cell, CD8 + T cell, B-cell, and macrophage activation, indicating that IRF3 and IRF7 could promote the anticancer effect of immune ... somerset county council ecologistWebApr 14, 2011 · cell line BJAB–IRF7 have shown that IRF7 induces a subset of pro-apoptotic proteins, as well as a group of mitochon- drial genes and genes affecting the DNA structure. somerset county council fab teamWebAug 1, 2024 · In addition, the IRF7 homology of birds and mammals is low, about 40% in geese, and even lower in chickens (Kim et al., 2024). Avian IRF7 has sequence similarity with mammalian IRF3 and IRF7, but it is not clear whether avian IRF7 has both immune regulation functions. Therefore, it is necessary to explore the immune regulation function of bird ... somerset county council dropped kerbIRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 tra… somerset county council foiWebTo gain insight into the function of the genes in the modules most affected by HAdV-7 infection, we used the Database for ... motifs, recruits myeloid differentiation primary response gene 88 (MyD88), leading to activation of IRF7 and NF-κB, which induce IFN-I and various chemokines and cytokines . The viral genome can be sensed by RNA ... somerset county council email address