WebbThe secondary alcohol was acylated in parallel with a series of differently substituted benzoic acid derivatives. Treatment with TFA-CH2Cl2 (5:995) released the expected saphenamycin analogues into solution. These new analogues were purified, characterized and screened for antimicrobial activity against Bacillus subtilis and Proteus mirabilis. WebbSaphenamycin is a novel and potent antibiotic. In the shopping cart is not goods, to choose and buy!
Bioorganisk og kombinatorisk kemi - KemiFOKUS
WebbThe secondary alcohol was acylated in parallel with a series of differently substituted benzoic acid derivatives. Treatment with TFA–CH2Cl2 (5:995) released the expected … WebbSaphenamycin has been synthesized from (R)-2 and 6-methyl salicylic acid with retention of enantiomeric excess and configuration.4 The butanoate of saphenic acid (4) (Scheme 1) is found to be active against several types of microorganisms, however, it has only been tested in racemic form and it is reasonable to believe children of camp blood
Solid-phase synthesis of new saphenamycin analogues with …
WebbLaursen JB, Jørgensen CG, Nielsen J. First synthesis of racemic saphenamycin and its enantiomers. investigation of biological activity. Bioorg Med Chem. 2003 Mar 6;11(5):723-31. PubMed PMID: 12538002. 4. Bahnmüller U, Keller-Schierlein W, Brandl M, Zähner H, Diddens H. Metabolites of microorganisms. 248. Synthetic analogs of saphenamycin. Webb© Royal Society of Chemistry 2024 Registered charity number: 207890 Publishing. Journals. Current Journals; Archive Journals; All Journals Webb1 sep. 2012 · Esmeraldins and saphenamycin, the PDC originated products, are antimicrobial and antitumor metabolites isolated from Streptomyces antibioticus Tü 2706. Herein, the esmeraldin biosynthetic gene cluster was identified on a dispensable giant plasmid. Twenty-four putative esm genes were characterized by bioinformatics, … government jobs for women